Skip to main content
padlock icon - secure page this page is secure

Surface Modified Self-Nanoemulsifying Formulations (SNEFs) For Oral Delivery of Gentamicin: In Vivo Toxicological and Pre- Clinical Chemistry Evaluations

Buy Article:

$68.00 + tax (Refund Policy)

Objective: This study aims to investigate the in vivo toxicological profile and pre-clinical safety of surface modified self-nanoemulsifying formulations (SNEFs) for oral delivery of a broad spectrum, anti-bacterial agent, gentamicin.

Method: SNEFs which were surface modified using PEG 4000, were formulated through water titration method using appropriate mixtures of soybean oil, a combination of Kolliphor ® EL and Kolliphor® P188 as surfactants, and Transcutol® HP as co-surfactant, and encapsulating gentamicin. SNEFs were characterized by measuring the droplet sizes, size distribution and surface charges using a Zetasizer. The effects of the SNEFs on body weight, haematological, biochemical, and histopathological factors of rats after oral administration were determined.

Results: Physicochemical characterization showed that the nanoformulations had droplet sizes ranging from 96 - 121 nm with surface charges of -32 to -36 mV. SNEFs did not show net suppression of body weights of rats. There were no clear indications of haematologic, hepatic and renal injuries in the study rats due to flip-flops in the levels of haematologic, hepatic and nephritic biomarkers evaluated. Histopathological organ examinations corroborated findings from the effect of SNEFs on the liver and kidney but revealed possible induction of astrocytosis in the cerebral cortex of rats.

Conclusion: Results of the study indicate that surface modified SNEFs of gentamicin have a promising pre-clinical safety potential with minimum toxicity effects.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Pre-clinical chemistry; gentamicin; haematological; histopathological; self-nanoemulsifying formulations; toxicological

Document Type: Research Article

Publication date: December 1, 2017

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more