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Carbopol 934-P Loaded with Vildagliptin for Diabetic Delivery: In Vitro and In Vivo Evaluation of Nanoparticles

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Vildagliptin-loaded mucoadhesive nanoparticles using Carbopol 934 P (CVN) as mucoadhesive polymer were prepared by Buchi Nano Spray Dryer to retain the drug in the stomach for a prolonged period of time and to provide sustainable release. The morphological properties of the nanoparticles were studied by scanning electron microscopy and found to have smoother surface with shriveled shape. Drug loading and the percentage recovery werefound to be 89.2 ± 0.5 and 96 ± 0.4 respectively. Bimodal particle size distribution with a mean of 355.8 nm and 80.15 nm was noticed. Angle of repose for CVN particles was relatively good with  < 32.4°. The percent swelling of CVN formulation was found to be 181±9%. In vivo studies in rats suggest that the vildagliptin was retained in the gastrointestinal tract(GIT) for prolonged period of time (∼12 h) and standard group was reduced significantly (∼3 h). Stability studies witnessed no changes when stored at 3-5°C or 15 – 25°C, except that the agglutinative phenomenon which was observed at 37°C and RH 75%. This study validates the mucoadhesive nanoparticles as one of the most appropriate drug delivery approaches for the effective delivery of vildagliptin.
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Keywords: Nanoparticles; carbopol; diabetic; shriveled; spraydrying; vildagliptin

Document Type: Research Article

Publication date: October 1, 2013

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  • Current Nanoscience publishes authoritative reviews and original research reports, written by experts in the field on all the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano- structures, synthesis, properties, assembly and devices. Applications of nanoscience in biotechnology, medicine, pharmaceuticals, physics, material science and electronics are also covered. The journal is essential to all involved in nanoscience and its applied areas.
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