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Liposomes: A Review of Manufacturing Techniques and Targeting Strategies

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Today, liposomes are among the most applied technologies for the encapsulation and delivery of bioactive agents and many different compounds in biological, pharmaceutical, medical and nutritional research. In this review, classification of liposomal vesicles, methods of their preparation and encapsulation, as well as their applications in food, cosmetics and pharmaceutical industries are reviewed. In addition, the main analytical approaches used to study liposome characteristics such as size, transition temperature, surface charge, fluidity, lamellarity, stability and encapsulation efficiency are presented. In the final part of the article, mechanisms of liposome targeting are discussed.

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Keywords: Liposome composition; active trapping; encapsulation efficiency; liposome characterization; liposome production; liposome stability; liposome targeting; oxidative stabilization; passive trapping; release mechanisms; transition temperature

Document Type: Research Article

Publication date: June 1, 2011

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  • Current Nanoscience publishes authoritative reviews and original research reports, written by experts in the field on all the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano- structures, synthesis, properties, assembly and devices. Applications of nanoscience in biotechnology, medicine, pharmaceuticals, physics, material science and electronics are also covered. The journal is essential to all involved in nanoscience and its applied areas.
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