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Therapeutic Nanoparticles and Associated Toxicity

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Nanoparticles (NPs) are currently widely used for different applications like cosmetics, personal care products and drug delivery agents. The enormous use and production of NPs resulted in release of NPs into the environment. These NPs find their way into aquatic, terrestrial and atmospheric environments. These NPs interact with their immediate environments and cause adverse affects on them. The rapidly growing field of nanotechnology will result in new routes of exposure through inhalation, ingestion, and injection. They can have damaging effects on cellular organells like mitochondria and macromoleculs like DNA. In view of this, there is a need to better understand the interactions between the NPs, environment and the organisms. In this article, we have reviewed the well known cytotoxicity assays and toxicity associated with therapeutic NPs.

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Keywords: Cytotoxicity; Metal NPs; Metal Oxide NPs; NPs; Nanotechnology; Nanotoxicity; Oxidative stress; Quantum Dots; Reactive oxygen species; Silica Nanomaterials

Document Type: Research Article

Publication date: June 1, 2011

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  • Current Nanoscience publishes authoritative reviews and original research reports, written by experts in the field on all the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano- structures, synthesis, properties, assembly and devices. Applications of nanoscience in biotechnology, medicine, pharmaceuticals, physics, material science and electronics are also covered. The journal is essential to all involved in nanoscience and its applied areas.
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