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PC12 Interaction with Magnetic Nanotubes: Effects on Viability, Cell Differentiation and Cell Translocation Induced by a Magnetic Field

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In this paper we used Multi Wall Carbon Nanotubes (MWCNTs) containing 3% of residuals and impurities of Fe, Al, and Zn. MWCNTs, by virtue of Fe at their tips, are able to respond to the effects of external magnetic fields. We demonstrated that MWCNTs interact with PC12 cells without compromising their viability and differentiation with outgrowth of neurites. We also document that when exposed to a magnetic field, both undifferentiated and differentiated PC12 cells cultured in CNT-containing medium solution are able to move towards the magnetic source.

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Keywords: Franz diffusion cells; Korsmeyer-Peppas; Nanoparticles; PLGA nanoparticles; amitriptyline; anti-allodynia; antinociception; cell displacement; chronic pain; doxepin; imipramine; in vitro release; magnetic materials; neuronal differentiation; neuropathic pain; tricyclic antidepressants

Document Type: Research Article

Publication date: June 1, 2011

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  • Current Nanoscience publishes authoritative reviews and original research reports, written by experts in the field on all the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano- structures, synthesis, properties, assembly and devices. Applications of nanoscience in biotechnology, medicine, pharmaceuticals, physics, material science and electronics are also covered. The journal is essential to all involved in nanoscience and its applied areas.
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