Oligomerization of G Protein-Coupled Receptors: Computational Methods
Successful prediction of GPCR complexes using computational approaches combined with experimental efforts may help to understand the role of dimeric/oligomeric GPCR complexes for fine-tuning receptor signaling. Moreover, since such GPCR complexes have attracted interest as potential drug target for diverse diseases, unveiling molecular determinants of dimerization/oligomerization can provide important implications for drug discovery.
Keywords: AFM; G protein-coupled receptor dimers; GPCR; chemokine CXCR4 receptor; molecular dynamics; protein-protein docking; protein-protein interfaces; sequence-based methods; structure-based methods; transmembrane proteins
Document Type: Research Article
Publication date: October 1, 2011
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