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Peptides for Tumour Therapy and Diagnosis: Current Status and Future Directions

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The use of peptides as targeting tools has been validated in different applications. In particular radiolabelled peptides with adequate stability, receptor-binding properties and biokinetic behaviour have been investigated as an important class of radiopharmaceuticals for cancer pathology imaging and therapy. This review focuses on recent progress in design and synthetic modifications of small biologically active peptides used in diagnosis and therapy. In particular, we report the current development and optimization of suitable peptides for targeting three relevant biological receptors (CCK, somatostatin, and integrin receptors) involved in specific tumour diseases.
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Keywords: CCK; integrin; somatostatin; structure-activity relationships; tumour diseases

Document Type: Research Article

Affiliations: Institute of Biostructures and Bioimaging, CNR and Department of Biological Sciences, University of Naples “Federico II”, via Mezzocannone 16, 80134, Napoli, Italy.

Publication date: 01 March 2009

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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