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Advances in Marine Natural Products of the Indole and Annelated Indole Series: Chemical and Biological Aspects

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Marine natural products, form a field of scientific endeavour, that has recently grown considerably. The isolation, biological evaluation, chemical properties and synthetic elaborations of products of marine organisms have attracted the attention of organic chemists, medicinal chemists, biologists and pharmacists. In this context a structurally and biologically highly interesting class is represented by the marine natural products containing an indole moiety in a pure substituted form or in an anella- ted form. The present review summarizes primarily the actual results concerning these products as new pharmacologically attractive lead compounds for drug design. The chemistry, biological evaluation and synthetic aspects are discussed. The spectrum of compounds represented comprises simply substituted indoles, peptidic products, dimeric indoles, anellated indoles and a variety of carbazoles. Most of them exhibit significant cytotoxicities.
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Keywords: Calothrix; Caulerpa racemosa; Caulerpa serulata; Dendrodoa grossularia; Hyrtios erecta; Indolyl-peptides; Leptoshaeria; Plasmodium falciparum; Rhopalaea; Sargassum tortile

Document Type: Review Article

Publication date: November 1, 2001

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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