Skip to main content
padlock icon - secure page this page is secure

Open Access Obesity as a Model of Premature Immunosenescence

Download Article:
(PDF 310.1 kb)
With aging the neuroendocrine-immune communication suffers an impairment, which explains the altered homeostasis and the resulting increase of morbidity and mortality. Since the aging process is very heterogeneous, the biological age determines the level of aging experienced by each individual and therefore his/her life expectancy. We have proposed several immune functions as markers of biological age and predictors of longevity, as well as the key involvement of the immune system in the rate of aging modulating oxi-inflamm-aging. This has been confirmed in several murine models of premature aging of neuroimmunomodulation such as poor response to stress, anxiety, depression or loss of estrogens. In the present article we summarize knowledge of the obesity and immune system and suggest that obese subjects, compared to non-obese of the same chronological age, are prematurely aged. Thus, we show some data supporting the hypothesis that obesity is a model of premature immunosenescence.

No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Ghrelin; Immune function; Leptin; Murine Models; immunosenescence; neuroendocrine-immune; neuroimmunomodulation; obesity; oxi-inflamm-aging; premature aging

Document Type: Research Article

Publication date: February 1, 2012

More about this publication?
  • Current Immunology Reviews publishes frontier reviews on all the latest advances in clinical immunology. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in clinical immunology.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more