Skip to main content
padlock icon - secure page this page is secure

Natural Tregs in Systemic Lupus Erythematosus

Buy Article:

$68.00 + tax (Refund Policy)

Regulatory CD4+ T cells are generated in the thymus and are distinguished from effector T cells by the expression of specific membrane antigens and by the intracellular expression of the transcription factor Foxp3. While the target antigens for regulatory T cells and their mechanisms of action remain poorly defined, several investigations have shown that these cells can contribute to the prevention of organ-specific autoimmunity. In the case of systemic autoimmune diseases such as systemic lupus erythematosus (SLE), it has recently emerged that regulatory T cells may play an important role in the control of the abnormal autoreactivity. The finding that the number of circulating Tregs decreases in active lupus patients and that the extent of such decrease correlates with clinical disease severity - together with the data obtained in murine models of lupus - have suggested the possibility of targeting Tregs for the modulation of the clinical course of SLE. This review highlights the advances and limitations of the studies on regulatory T cells in SLE, and critically discusses the most recent findings in this rapidly evolving field.





No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: CD4+CD25+ regulatory T cells (Tregs); Systemic lupus erythematosus (SLE); autoimmunity; immune tolerance

Document Type: Research Article

Publication date: February 1, 2008

More about this publication?
  • Current Immunology Reviews publishes frontier reviews on all the latest advances in clinical immunology. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in clinical immunology.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more