Skip to main content
padlock icon - secure page this page is secure

Regulation of Adaptive Immunity by the Neurotransmitter Norepinephrine

Buy Article:

$68.00 + tax (Refund Policy)

Endogenous physiological mechanisms are in place to regulate cell activity in organ systems to maintain host homeostasis when challenged. Antigenic exposure is an example of a challenge that disrupts host homeostasis. During this challenge, activated immune cells secrete cytokines that influence central nervous system activity, which in turn activates the peripheral sympathetic nervous system to release the neurotransmitter norepinephrine from nerve terminals located within lymphoid tissues. Norepinephrine binds to the beta2-adrenergic receptor expressed on immune cells to regulate the level of gene expression and the magnitude of an immune response. In this review, we will discuss both in vitro and in vivo findings that indicate the cellular and molecular mechanisms by which norepinephrine stimulation of the beta2- adrenergic receptor on CD4+ T cells and B cells regulates the level of cellular activity to maintain host homeostasis.





No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: B cell; CD4+ T cell; Sympathetic nervous system; antibody; norepinephrine

Document Type: Research Article

Publication date: November 1, 2006

More about this publication?
  • Current Immunology Reviews publishes frontier reviews on all the latest advances in clinical immunology. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in clinical immunology.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more