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Comparison and Impact of The Short-Term Use of Some Non-Aspirin NSAIDs on Bleeding Time of Mice

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Background: Non-Steroidal Anti Inflammation Drugs (NSAIDs) have shown effectivity in pain relief and are the most prescribed around the world. However, NSAIDs impair hematological aspects that may lead to the life-threatening events.

Objective: The objective of the study is to determine the comparison and impact of the short-term use of some non-aspirin NSAIDs on bleeding time.

Method: We have 10 animals group. Each group contains 4 animals. Normal group, ketoprofen (0.26 mg/ 20 g BW of mice twice daily), ketorolac (0.078 mg/ 20 g BW of mice twice daily), diclofenac (0.13 mg/ 20 g BW of mice twice daily), piroxicam (0.052 mg/ 20 g BW of mice once daily), mefenamic acid (1.3 mg/ 20 g BW of mice thrice daily), meloxicam (0.039 mg/ 20 g BW of mice once daily), celecoxib (0.52 mg/ 20 g BW of mice once daily), ibuprofen (1.04 mg/ 20 g BW of mice thrice daily) and paracetamol group (1.3 mg/ 20 g BW of mice thrice daily). The treatment length is 5 days. Bleeding time determination was conducted one hour after the last treatment.

Results: All test group showed an elevation of the bleeding time by 59.78%, 156.50%, 108.73%, 99.96%, 22.59%, 85.46%, 69.66%, 42.24%, and 45.08% for meloxicam, ketoprofen, ketorolac, diclofenac sodium, paracetamol, piroxicam, mefenamic acid, ibuprofen and celecoxib than normal groups, respectively. Ketoprofen gives the highest bleeding time elevation.

Conclusion: Ketoprofen gives the highest bleeding time elevation while paracetamol gives the lowest bleeding time elevation.
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Keywords: Bleeding time; NSAIDs non-aspirin; hemorrhage; impact; life-threatening; short-term

Document Type: Research Article

Publication date: November 1, 2018

More about this publication?
  • Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry.

    Cardiovascular & Hematological Agents in Medicinal Chemistry
    is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.
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