Skip to main content
padlock icon - secure page this page is secure

Association Between Waist Circumference and Magnesium and Uric Acid in Indigenous Argentinean Children Living at High Altitude

Buy Article:

$68.00 + tax (Refund Policy)

Background: Non-traditional risk factors including low levels of magnesium and high levels of uric acid have been associated with central obesity and cardiovascular disease.

Objective: To determine the association between waist circumference (WC) and non-traditional risk factors such as magnesium, phosphorus, and uric acid in indigenous children living at high altitudes.

Methods: A total of 354 (166 M) indigenous school children, aged 9.6 + 2.3 years, were enrolled in a cross-sectional study in November 2011. Central obesity was defined as WC ≥ 90th percentile according to age and sex. Low magnesium and phosphorus levels were defined as serum magnesium <1.8 mg/dL and phosphorus <2.4 mg/dL. Hyperuricemia was defined as serum uric acid > 7 mg/dL.

Results: The prevalence of central obesity was 6.8% (24/354). None of the children had hyperuricemia or low phosphorus levels. Hypoagnesemia was identified in 21.7% (57/263). There was a significant association between WC (z-score) and magnesium (r-015), uric acid (r0.28), phosphorus (r-0.30), HOMAIR (r0.49), triglycerides (r0.24), and HDL-C (r0.24). However, calcium, sodium, and potassium were not significantly associated with WC. As z-WC quartiles increased magnesium and phosphorus levels significantly decreased, whereas uric acid levels increased. Multiple linear regression analysis showed that z-WC was associated significantly and directly with uric acid (B0.31), triglycerides (B0.004), and HOMA-IR (B0.35); and inversely with magnesium (B-0.83) and phosphorus (B-0.25), adjusted for confounding variables (R2 0.34).

Conclusion: Our results indicate that central obesity was associated significantly and inversely with magnesium and phosphorus and directly with uric acid in indigenous school children. Supplementation with magnesium and/or phosphorus could prevent future cardiovascular disease. Prospective and randomized studies should be performed to confirm these findings.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: High altitude; indigenous children; magnesium; phosphorus; uric acid; waist circumference

Document Type: Research Article

Publication date: August 1, 2016

More about this publication?
  • Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry.

    Cardiovascular & Hematological Agents in Medicinal Chemistry
    is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more