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An In Situ Procedure; Grinding Synthesis of 4H-benzo[h]chromene-3- carbonitriles Using DBU-hydrobromide-perbromide

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Background: A clean and environmentally benign route to 4H-benzo[h]chromene-3- carbonitriles has been developed via three-component condensation reaction of various benzyl alcohols, malononitrile and 1-naphthol using DBU-hydrobromide-perbromide as an efficient oxidizing reagent at room temperature.

Methodology: The present methodology offers several advantages such as solvent-free conditions, excellent yields, simple procedure, mild conditions and reduced environmental consequences.

Conclusion: All of synthesized compounds were characterized by IR, NMR and elemental analyses.

Keywords: 1-Naphthol; Chromene; TFE; benzyl alcohol; malononitrile; multicomponent reaction

Document Type: Research Article

Publication date: August 1, 2017

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