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Inhibitors of Laccases: A Review

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Laccases are an interesting group of multicopper enzymes, which have received much attention of researchers in last decades due to their ability to oxidise both phenolic and non-phenolic lignin-related compounds as well as highly recalcitrant environmental pollutants. This makes these biocatalysts very useful for their application to several biotechnological processes. Soil and water contamination is often accompanied by several organic and inorganic compounds. Therefore, it is important to know the stability of laccases under the conditions present in such environments, since it can influence the effectiveness of the bioremediation technologies. Recently, the utility of laccases has also been applied to Nanobiotechnology. This is an increasing research field mainly due to the fact that laccases are able to catalyse electron transfer reactions without additional cofactors and to the development of several techniques for the immobilisation of biomolecules such as micropatterning, self-assembled monolayers and layer-by-layer technique. These techniques can be used to immobilise laccases preserving their enzymatic activity. This paper reviews the effect of the potential laccase inhibitors that can be found in polluted environments on laccase activity.

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Keywords: Bioremediation; biotechnology; contamination; immobilisation; inhibitors; laccases; nanotechnology

Document Type: Research Article

Affiliations: Department of Chemical Engineering, Rovira i Virgili University, Av. Paisos Catalans 26, 43007 Tarragona, Spain.

Publication date: November 1, 2006

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  • Current Enzyme Inhibition aims to publish all the latest and outstanding developments in enzyme inhibition studies with regards to the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of enzymes that can be exploited for drug development. Current Enzyme Inhibition is an essential journal for every pharmaceutical and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.
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