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Chemokines and Chemokine Receptors as Targets in the Therapy of Psoriasis

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Chemokines are members of a superfamily of small, cytokine-like, chemotactic proteins that have recently been shown to critically regulate leukocyte trafficking. Accumulating evidence indicates that the chronically relapsing inflammatory skin disease psoriasis represents a T cell-mediated disease. Thus, the understanding of the underlying mechanisms of memory T cell homing to the skin may provide promising targets for the development of novel therapeutics. Here results of recent studies associating chemokines with a psoriatic phenotype and delineating their role in the recruitment of memory T cells to the skin are discussed.
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Keywords: cccr10; ccr4; ccr6; chemokine receptors; chemokines; cxcr3; psoriasis; therapy

Document Type: Review Article

Affiliations: Dept. of Dermatology,Heinrich-Heine-University, Moorenstr.5, 40225 Düsseldorf, Germany.

Publication date: June 1, 2004

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