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Cancer Metastasis, a Clinical Dilemma for Therapeutics

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Background: More than 90% of cancer deaths are caused by cancer metastasis. Cancer metastatic therapy is a top priority topic.

Objective: New therapeutics against cancer metastasis is to be discovered.

Methods: In the past pathogenesis study, a therapeutic dilemma has been discovered from literatures of epithelial-mesenchymal cell interchange in late-staged cancer patients—opposite tumor pathogenesis routes between primary and metastatic tumors.

Results: Possible options for overcoming this dilemma are enlisted from different therapeutic attempts (such as novel drug target (cancer biomarkers) discovery, antimetastatic drug developments, biotherapies, drug combinations, cancer therapeutics according to metastatic cascades, different types of personalized medicine paradigms and so on).

Conclusions: These therapeutic options might change the landscape of cancer treatments and managements in clinics forever.
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Keywords: Neoplasm metastases; cancer chemotherapy; drug combination; drug sensitivity testing; personalized cancer therapy; personalized medicine; pharmacogenetics

Document Type: Research Article

Publication date: August 1, 2016

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  • Current Drug Therapy publishes frontier reviews on all the latest advances in drug therapy. The journal's aim is to publish the highest quality review articles in the field. Topics covered include: new and existing drugs, therapies and medical devices.

    The journal is essential reading for all researchers and clinicians involved in drug therapy.
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