5-ht6 Receptors
The 5-hydroxytryptamine6 (5-ht6) was one of the most recent additions to the5-HT receptor family, selective antagonists have recently been developed and potentialfunctional roles are now becoming apparent. The high affinity of a wide range ofpsychiatric drugs for the 5-ht6 receptor, together with its almost exclusive expression inthe CNS, being abundant in limbic and cortical regions, has stimulated significantresearch interest. The 5-ht6 receptor appears to regulate glutamatergic and cholinergicneuronal activity, and increasing evidence suggests that it may be involved in the regulationof cognition, feeding and, possibly, affective state and seizures. The current article will review all aspectsof the discovery, genetics, distribution, pharmacology and function of the 5-ht6 receptor. Taken together, thiswealth of information warrants the use of the upper case nomenclature for the 5-ht6 receptor to be approved andits true status recognised.
Keywords: 5-hydroxytryptamine6; cholinergicneuronal
Document Type: Review Article
Affiliations: Institute of Neuroscience,School of Biomedical Science, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.
Publication date: 01 February 2004
- CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will contain a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in neurological and CNS disorders. As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.
- Access Key
- Free content
- Partial Free content
- New content
- Open access content
- Partial Open access content
- Subscribed content
- Partial Subscribed content
- Free trial content