Research Progress of Progesterone Preparations: A Mini Review
Background: Progesterone is a sex steroid hormone. Since it has been discovered, it is widely used in the prevention of spontaneous preterm birth, hormone replacement therapy and other gynecological conditions.
Methods: We will review the progesterone preparations based on a comprehensive study of papers and patents from the traditional preparations up through the very recent literatures.
Results: This review mainly concentrates on oral, vaginal and micro delivery systems, involving different ways to prepare progesterone preparations.
Conclusion: Although progesterone has first-pass effects, with these methods, the bioavailability and compliance can be greatly increased.
Methods: We will review the progesterone preparations based on a comprehensive study of papers and patents from the traditional preparations up through the very recent literatures.
Results: This review mainly concentrates on oral, vaginal and micro delivery systems, involving different ways to prepare progesterone preparations.
Conclusion: Although progesterone has first-pass effects, with these methods, the bioavailability and compliance can be greatly increased.
Keywords: Delivery system; injection; microspheres; oral; progesterone preparations; vaginal
Document Type: Review Article
Publication date: 01 August 2018
This article was made available online on 30 May 2018 as a Fast Track article with title: "Research Progress of Progesterone Preparations: A Mini Review".
- Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:
In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts. - Editorial Board
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