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Structure Activity Relationship of Venom Toxins Targeting Potassium Channels

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Background: Peptide toxins are naturally occurring rich sources of highly specific bioactive compounds from venomous animals acting on various types of ion channels.

Objective: This study mainly highlights targeting of one of the largest families of ion channels i.e. potassium channels via venom toxins.

Method: Data for reported venom toxins from diverse species is gathered and analyzed at sequence and structural extent.

Results: The similarities and differences among toxins have been demonstrated along with structure activity relationship of potassium channels with these toxins.

Conclusion: This review highlights the importance of functionally important residues and structural scaffolds of venoms interacting with potassium channels.
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Keywords: Venom toxins; disulphide bridges; gating modifiers; kunitz type toxins; pore blockers; potassium channels; structure scaffolds

Document Type: Review Article

Publication date: July 1, 2018

This article was made available online on January 18, 2018 as a Fast Track article with title: "Structure Activity Relationship of Venom Toxins Targeting Potassium Channels".

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  • Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

    In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.
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