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Application of Medicinal Plants as a Source for Therapeutic Agents Against Streptococcus pyogenes Infections

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Background: Streptococcus pyogenes, a major human pathogen, causes a wide variety of invasive systemic infections such as acute pharyngitis, skin and soft-tissue infections, especially necrotizing fasciitis.

Objective: This review focuses on the properties of pathogenicity of S. pyogenes and outlines ways to combat infection caused by these bacteria through alternative plant-based medicine.

Conclusion: This Gram positive bacterium has an ability to form mature biofilm and this sessile life style plays an important role in S. pyogenes pathogenicity. The virulence of these bacteria is further strengthened by its ability to communicate within the micro-colonies through quorum sensing. Most treatments are now aimed at either elimination of this bacterium or suppression of its virulence. The emergence of antibiotic resistance among S. pyogenes and treatment failure has become an added concern globally. One of its virulence properties, biofilm formation, has made it more resistant to antibiotic therapy. This has vitalized the necessity for searching alternative therapies for its treatment. The growing research in herbal medicines has led to the discovery of various phytochemicals to limit the virulence of S. pyogenes.
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Keywords: Group A streptococcus; antibiotic resistance; biofilm; pharyngitis; phytochemicals; quorum sensing

Document Type: Review Article

Publication date: July 1, 2018

This article was made available online on April 6, 2018 as a Fast Track article with title: "Application of Medicinal Plants as a Source for Therapeutic Agents Against Streptococcus pyogenes Infections".

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  • Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

    In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.
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