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Advances in Nanostructure-mediated Hyperthermia in Tumor Therapies

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Background: Hyperthermia has been proposed as a promising treatment modality for its advantageous profiles such as mini/non-invasiveness, good tolerability and cost-effectiveness. Quick development of nanotechnology in recent years has greatly broadened the application area of hyperthermia and endowed it with attractive new functions. This review aims to present an overview of different nanostructures mediated hyperthermia in terms of external stimuli source.

Methods: We performed to review for the development and current status of nanostructure-mediated hyperthermia, by searching MEDLINE, EMBASE, and Cochrane Library database for identification of relevant articles.

Results: In the present study, the systemic results of hyperthermia mediated by nanostructures were researched, and five different kinds of external sources were found and listed in this review. The brief mechanism and commonly explored nanostructures were introduced and then combined therapies of nanostructure-mediated hyperthermia stimulated by different external sources were investigated. Finally, challenges with current nanostructures mediated hyperthermia were discussed in order to give advice to the future development of nanostructure-mediated hyperthermia.

Conclusions: Despite all the achievements the new technology of nanostructure-mediated hyperthermia have made in pre-clinical animal experiments, there are still much to be pursued in the further development to be biocompatible, effective and precise.

Keywords: Hyperthermia; magnetic field; microwave; nanostructure; photothermal; radiofrequency; ultrasound

Document Type: Review Article

Publication date: February 1, 2018

This article was made available online on February 7, 2018 as a Fast Track article with title: "Advances in Nanostructure-mediated Hyperthermia in Tumor Therapies".

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  • Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

    In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.
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