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Conjugation Strategies for Colonic Delivery and its Application in Colorectal Cancer Therapy

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Background: Efficient colon-specific drug delivery has been demonstrated recently in the treatment of various diseases, including Crohn's disease, ulcerative colitis (inflammatory bowel disease), and colorectal cancer.

Methods: Of all strategies, the conjugation of a model drug to a carrier (with or without spacers) has been recognized as promising for targeting the colon.

Results: This is because the conjugation method releases large amounts of the drug while reducing the amount of the drug released in the stomach and small intestine.

Conclusion: This review focuses on the design of linkage conjugates that carry out specific delivery to the colon. The types of conjugation for application in colorectal cancer therapy will be discussed as well.
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Keywords: Colon-specific delivery; colorectal cancer; conjugate; drug delivery; linkage conjugates; targeting

Document Type: Review Article

Publication date: November 1, 2017

This article was made available online on November 13, 2017 as a Fast Track article with title: "Conjugation Strategies for Colonic Delivery and its Applicationin Colorectal Cancer Therapy".

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  • Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

    In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.
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