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Nanoprecipitation for Poorly Water-Soluble Drugs

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Background: More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects.

Methods: Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up.

Results: However, there are two technical issues of concern related to this method. First, the two solvents used for this approach must be miscible; concomitantly, the drug has to be soluble enough in a solvent but not in the antisolvent. Second, the particle growth needs to be adjusted by surfactant addition.

Conclusion: In this review, nanoprecipitation methods and solvent removal techniques for poorly water soluble drugs will be discussed.
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Keywords: Nanoprecipitation; anti-solvent; nanoparticulate; poorly water-soluble drug; solvent removal technique; surfactant

Document Type: Review Article

Publication date: November 1, 2017

This article was made available online on October 17, 2017 as a Fast Track article with title: "Nanoprecipitation for Poorly Water-Soluble Drugs".

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  • Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

    In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.
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