Drug Metabolism and Pharmacokinetics of Dammarane Triterpenoids
Dammarane triterpenoids are widely distributed in plants and are implicated in various bioactivities and pharmacological effects. This review focuses on advancements in dammarane triterpenoid metabolism, particularly drug design and development, including radiolabeling, absorption, distribution, metabolism, excretion, and pharmacokinetics, which can accurately describe the behaviors of dammarane triterpenoids. This review contributes to the systematic and consistent research and development of dammarane triterpenoids. Their structures and activities, radiolabel application, absorption, distribution, and pharmacokinetic characteristics, possible degradation pathways, metabolic enzyme induction or inhibitory effect, and structure-activity relationships have been described. New intranasal and intra-tympanic administration routes and microdialysis technology have also been introduced. These techniques not only improve the limits of dammarane triterpenoids on absorption and distribution but also facilitate the design and study of these compounds as potential drugs.
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Document Type: Research Article
Publication date: November 1, 2016
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- Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:
In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.
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