Disposition of Nanoparticle-Based Delivery System via Inner Ear Administration
Keywords: Corti's liquid; Nanoparticles; Reissner's membrane; Rhodamine; Rosenthal's canal; anatomic barri-ers; blood capillaries; blood-inner ear barrier; cerebrospinal fluid; cochlea; concentration; configuration; dimethylsulfoxide; green fluorescent protein; hyaluronic acid; hydroxyapatite nanoparticles; intratympanic administration; intratympanic injection; lipid nanoparticles; liposolubility; liposomes; local drug delivery; maghemite; magnetite; microhomeostasis; micropinocytic vesicles; osmotic effects; otologic treatments; perilymph; pheochromocytoma cells; polymersomes; round window; round window membrane; scala tympan; scala vestibuli; sensorineural; spiral ganglion; therapeutic agents; tunnel fibers; tympani; tympanic membrane
Document Type: Research Article
Publication date: 01 December 2010
- Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:
In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts. - Editorial Board
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