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Pharmacokinetics and Disposition of Various Drug Loaded Biodegradable Poly(Lactide-Co-Glycolide) (PLGA) Nanoparticles

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Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PLGANPs) have been widely investigated for sustained and targeted delivery of various drugs including small molecular drugs (hydrophobic/ hydrophilic drugs) and macromolecule drugs (such as proteins, peptides, genes, vaccines, antigens, human growth factors, etc.). The in vivo pharmacokinetics and disposition profile of these encapsulated drugs and PLGANPs themselves is a key factor that determines their therapeutic index and potential for clinical use. Therefore, this review attempts to outline the in vivo behaviors of diverse drugs loaded PLGANPs administrated via different routes such as oral route, intravenous injection, nasal path, etc. . Also, the associated analytical techniques used to investigate the in vivo disposition of PLGANPs loaded with drugs are focused on.

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Keywords: Analytical technique; PLGA; Polylactic-co-glycolic acid; Tmx-NPs; Toxoplasma; biocompatible polymers; disposition; distribution; hepatotoxicity; hydrophilic drugs; hydrophobic drugs; in vivo behavior; nanoparticles; paclitaxel; pharmacokinetics

Document Type: Research Article

Publication date: December 1, 2010

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  • Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

    In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.
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