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Home / Current Drug Metabolism, Volume 8, Number 3

IDO and Clinical Conditions Associated with Depressive Symptoms

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In the pathogenesis of depressive symptoms the neurotransmitter serotonin plays an important role - although the underlining mechanisms are still not clear. The synthesis of serotonin is dependent on the availability of tryptophan - an amino acid that is linked to the immune system by its catabolism via the enzyme indoleamine-2,3-dioxygenase (IDO). Based on this connection research approaches addressing different clinical conditions with depressive symptoms and immunological involvement have been considered. This review provides an overview on the latest research in the field.





Keywords: Depression; IDO activity; cytokine treatment; immune activation; pregnancy; somatic diseases; tryptophan

Document Type: Research Article

Affiliations: Department of Biological Psychiatry, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck,Austria.

Publication date: 01 April 2007

More about this publication?
  • Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

    In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.
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