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Preface [Hot Topic: Cytochrome P450 and Diseases: Implications in Drug Metabolism and Pathophysiology (Guest Editor: Vincent Pichette)]

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Several decades ago, scientists showed the existence of a hemoprotein implicated in the metabolism of foreign and endogenous compounds. This enzyme was further shown to be part of a superfamily named cytochrome P450 (CYP450). Today, this family comprises more than 150 different isoforms distributed among multicellular organisms such as animals, vegetables as well as fungi. CYP450 is implicated in the metabolism of lipids, steroids, vitamins, bile acids, prostaglandins and many other endogenous molecules. Thus, it is essential for homeostasis.

But CYP450 does much more than that. It is directly implicated in the elimination of toxic substances which can interfere with body functions if they accumulate. CYP450 plays also a key role in the acquisition of toxic characteristics by some xenobiotics like heterocyclic aromatic amines that are metabolized to carcinogenic products. Finally, studies of the CYP450 enlighten its outstanding participation in the metabolism of numerous drugs that are used in modern medicine. Recently, CYP450 research has focussed on its role in the pathophysiology of common diseases, particularly cancer and hypertension.

Here, we exhaustively review certain diseases where CYP450 is either modified by a particular clinical situation, or implicated in the pathophysiology. Thus, senior authors have reviewed the current knowledge on the impact of liver diseases, inflammation, hypoxia and stroke on the activity of CYP450 and, consequently on the metabolism of various molecules. The direct or indirect implications of CYP450 in the pathophysiology of several conditions such as hypertension, cancer, and brain dysfunction are also review.
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Document Type: Book Review

Affiliations: Universite of Montreal Centre de Recherche Guy Bernier Hopital Misonneuve-Rosemont 5415 boul. de l' Assomption, Montreal, Quebec, Canada H1T 2M4

Publication date: June 1, 2004

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  • Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments. The journal covers the following areas:

    In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites and adducts.
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