Investigation of Methylene Blue Release from Functional Polymeric Systems Using Dielectric Analysis
Objective: The aim of this study was to investigate the dielectric characteristics of functional polymeric systems containing MB and their influence on mucoadhesion and drug release.
Methods: Binary polymeric systems containing different concentrations of poloxamer 407, Carbopol 934P and MB were evaluated as dielectric and mucoadhesive properties, as well as in vitro drug release profile.
Results: MB, temperature and polymeric composition influenced the physicochemical properties of the systems. The presence of MB altered the supramolecular structure of the preparations. The mucoadhesive properties of systems were influenced by MB presence and the formulation with the lowest amount of MB displayed faster release.
Conclusion: The lower MB concentration in the systems displayed better results in terms of ionic mobility and drug release, and is indicative of a suitable clinical performance.
Document Type: Research Article
Publication date: January 1, 2018
This article was made available online on August 21, 2017 as a Fast Track article with title: "Investigation of Methylene Blue Release from Functional Polymeric Systems Using Dielectric Analysis".
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