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Receptor Mediated Tumor Targeting: An Emerging Approach for Cancer Therapy

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Receptor-mediated tumor targeting has received major attention in the field of cancer drug delivery in the past few years. Receptors, as molecular target has opened new opportunities for cellular or intracellular targeting of drug loaded delivery systems conjugated with targeting moieties i.e. ligand. This receptor mediated targeting of cancer drug through nano carrier systems to cancerous tissue offer protection and improves the pharmacokinetics of various drugs and help to overcome the systemic toxicity and adverse effects that result from the non-selective nature of most current cancer therapeutic agents. The article reviews the scope of receptor mediated targeting of anticancer drug loaded in various nanocarriers and also summarize recent perspective and challenges in the field of nanocarrier-aided drug delivery and drug targeting for cancer therapy.

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Keywords: Artemisinin; Bevacizumab; Intercellular cell adhesion molecule-1; Isoaspartate-glycine-arginine; PEG stealth liposomes; Prostate specific membrane antigen; Receptor; Tf-coupled poly(ethylene glycol); amphiregulin; apotransferrin; basic fibroblast growth factor; betacellulin; boron neutron capture therapy; diapedesis; docetaxel; doxorubicin; doxorubicin-loaded immunoliposomes; enhanced permeability and retention; ferrotransferrin; folate receptor; glycerol monooleate coated magnetic nanoparticles; heparin-binding EGF; ligand; lysosomes; methotrexate; nanocarrier; polymer arabinogalactan; prostate-specific membrane antigens; transferrin receptor; transforming growth factor-; tumor targeting; vascular endothelial growth factor

Document Type: Research Article

Publication date: January 1, 2011

More about this publication?
  • The aim of Current Drug Delivery is to publish peer-reviewed articles, short communications, short and in-depth reviews in the rapidly developing field of drug delivery. Modern drug research aims to build in delivery properties of a drug at the design phase, however in many cases this ideal cannot be met and the development of delivery systems becomes as important as the development as the drugs themselves.

    The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance.

    The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.
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