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Role of Differential Signaling Pathways and Oxidative Stress in Diabetic Cardiomyopathy

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Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary artery disease in diabetes mellitus. There is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Hyperglycemia- induced oxidative stress is a major risk factor for the development of micro-vascular pathogenesis in the diabetic myocardium, which results in myocardial cell death, hypertrophy, fibrosis, abnormalities of calcium homeostasis and endothelial dysfunction. Diabetes-mediated biochemical changes show cross-interaction and complex interplay culminating in the activation of several intracellular signaling molecules. Diabetic cardiomyopathy is characterized by morphologic and structural changes in the myocardium and coronary vasculature mediated by the activation of various signaling pathways. This review focuses on the oxidative stress and signaling pathways in the pathogenesis of the cardiovascular complications of diabetes, which underlie the development and progression of diabetic cardiomyopathy.





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Keywords: (MHC); Diabetes mellitus; Hyperglycemia-induced; JNK; LV hypertrophy; NFATc3; OLETF; STREPTOZOTOCIN; TGF1; apoptosis; autocoids; cardiomyocytes; cardiomyopathy; clinical manifestation; dephosphory-lation; diabetic cardiomyopathy; fibrosis; glutathione peroxidase; hemodynamics; histopathological; hypertrophy; inflammation; non-phagocytic; overstimulation; oxidative stress; peroxisome proliferator; postinfarction; presumably; pro-apoptotic; sarcolemmal membrane; sarcoplasmic reticulum; systolic dysfunction; translocation; viral infection

Document Type: Research Article

Publication date: November 1, 2010

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  • Current Cardiology Reviews publishes frontier reviews on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in cardiology.
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