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Molecular Determinants of Fluoroquinolone Antibacterial Agents Pharmacokinetics

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This review presents the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.





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Keywords: Fluoroquinolone; ciprofloxacin; drug transporters; enzymes; levofloxacin; moxifloxacin; ofloxacin; pharmacokinetics

Document Type: Research Article

Publication date: 01 September 2009

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  • Current Clinical Pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. The journal's aim is to publish the highest quality review articles in the field. Topics covered include: pharmacokinetics; therapeutic trials; adverse drug reactions; drug interactions; drug metabolism; pharmacoepidemiology; and drug development. The journal is essential reading for all researchers in clinical pharmacology.
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