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A Novel Gene Selection Method Based on Sparse Representation and Max-Relevance and Min-Redundancy

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Aim and Objective: Gene selection method as an important data preprocessing work has been followed. The criteria Maximum relevance and minimum redundancy (MRMR) has been commonly used for gene selection, which has a satisfactory performance in evaluating the correlation between two genes. However, for viewing genes in isolation, it ignores the influence of other genes.

Methods: In this study, we propose a new method based on sparse representation and MRMR algorithm (SRCMRM), using the sparse representation coefficient to represent the relevance of genes and correlation between genes and categories. The SRCMRMR algorithm contains two steps. Firstly, the genes irrelevant to the classification target are removed by using sparse representation coefficient. Secondly, sparse representation coefficient is used to calculate the correlation between genes and the most representative gene with the highest evaluation.

Results: To validate the performance of the SRCMRM, our method is compared with various algorithms. The proposed method achieves better classification accuracy for all datasets.

Conclusion: The effectiveness and stability of our method have been proven through various experiments, which means that our method has practical significance.
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Keywords: MRMR; Sparse representation; gene selection

Document Type: Research Article

Publication date: February 1, 2017

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  • Combinatorial Chemistry & High Throughput Screening publishes full length original research articles and reviews describing various topics in combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) and/or high throughput screening (e.g. developmental, practical or theoretical). Ancillary subjects of key importance, such as robotics and informatics, will also be covered by the journal. In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discoveryand development, in the settings of industry, academia or government.
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