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Parallel Solution-Phase Synthesis of a 2-Aminothiazole Library Including Fully Automated Work-Up

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A straightforward and effective procedure for the solution phase preparation of a 2-aminothiazole combinatorial library is described. Reaction, work-up and isolation of the title compounds as free bases was accomplished in a fully automated fashion using the Chemspeed ASW 2000 automated synthesizer. The compounds were obtained in good yields and excellent purities without any further purification procedure.





Keywords: Alzheimer's disease; Aminothiazole; Chemspeed ASW 2000 automated; DMF; H NMR spectroscopy; Huntington's disease; automation; chronic pain; combinatorial chemistry; solution phase synthesis; triethylamine

Document Type: Research Article

Publication date: 01 February 2011

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  • Combinatorial Chemistry & High Throughput Screening publishes full length original research articles and reviews describing various topics in combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) and/or high throughput screening (e.g. developmental, practical or theoretical). Ancillary subjects of key importance, such as robotics and informatics, will also be covered by the journal. In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discoveryand development, in the settings of industry, academia or government.
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