Dual Opposed Survival-supporting and Death-promoting Roles of Autophagy in Cancer Cells: A Concise Review
Autophagy is a well-maintained process by which the cells recycle intracellular materials to maintain homeostasis in various cellular functions. However, autophagy is a defensive mechanism that maintains cell survival under antagonistic conditions, the induction of the autophagic process may substantially lead to cell death. The conflicting roles of autophagy including allowing cell survival or promoting cell death could have a troublesome impact on the efficiency of chemotherapeutic agents. Accordingly, understanding the role of autophagy in cancer is a vital need for its optimal manipulation in therapy.
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Document Type: Review Article
Publication date: March 1, 2020
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- Current Chemical Biology aims to publish full-length and mini reviews on exciting new developments at the chemistry-biology interface, covering topics relating to Chemical Synthesis, Science at Chemistry-Biology Interface and Chemical Mechanisms of Biological Systems.
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Science at Chemistry-Biology Interface (Chemical informatics; Macromolecular catalysts and receptors; Enzymatic synthesis; Biosynthetic engineering; Combinatorial biosynthesis; Plant cell based chemistry; Bacterial and viral cell based chemistry; Chemistry of cellular processes in plants/animals; Receptor chemistry; Cell signaling chemistry; Drug design through understanding of disease processes; Synthetic biology; New high throughput screening techniques; Small molecular array fabrication; Chemical genomics; Chemical and biological approaches to carbohydrates proteins and nucleic acids design; Chemical and biological regulation of biosynthetic pathways; and Unnatural biomolecular analogs).
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