Targeting Bcl-2 Family of Proteins: An Important Strategy in Cancer Therapeutics
Keywords: Anti-sense Agent (Oblimersen Sodium); Apogossypolone; Apoptosis; Autoimmunity; BCL-2; Cancer; Docetaxel; Extrinsic; Gossypol Derivatives; Hodgkins disease, leukemia; INHIBITORS; Intrinsic pathways; Lead optimization; Molecule Antagonist; Peptides; Peptidomimetics; Proteins; Synergy with agents; T lymphoid cells; Terphenyl derivatives; Therapeutics; abnormal growth; acute lymphoblastic leukemia; analogues; anti apoptotic; anticancer drug discovery; antiproliferative; benzoyl urea frame work; binding affinity; breast; breast cancers; cancer; carcinomas; caspase; cell death; cell division; cell lymphoma; cell shrinkage, membrane blebbing; chemotherapy; chromatin condensation; chromosomes; chronic lymphocytic leukemia; colorectal adenocarcinomas; cytotoxic agents; dendrite cells; embryogenesis; enantiomer; gene translocation; genetic information; gossypol; growth; homeostasis; mRNA; melanoma; micromolar affinity; migration of cells; mitochondrial membrane; mitochondrial outer membrane permeabilization (MOMP); multiple myeloma; mutations to DNA; myeloid lymphoma; neuronal cells; non-vital cell; oligonucleotide drug; oncogenic signal; patent protection; peripheral tolerance; pharmaceuticals; pharmacokinetic; pro-apoptotic; proliferation; prostate; proteolytic enzymes; purpurogallin; racemate; radiotherapy; screening combinatorial; self-antigen; sperms cells; thrombocytopenia; tumor; uclear fragmentation
Document Type: Research Article
Publication date: January 1, 2011
- Current Chemical Biology aims to publish full-length and mini reviews on exciting new developments at the chemistry-biology interface, covering topics relating to Chemical Synthesis, Science at Chemistry-Biology Interface and Chemical Mechanisms of Biological Systems.
Current Chemical Biology covers the following areas: Chemical Synthesis (Syntheses of biologically important macromolecules including proteins, polypeptides, oligonucleotides, oligosaccharides etc.; Asymmetric synthesis; Combinatorial synthesis; Diversity-oriented synthesis; Template-directed synthesis; Biomimetic synthesis; Solid phase biomolecular synthesis; Synthesis of small biomolecules: amino acids, peptides, lipids, carbohydrates and nucleosides; and Natural product synthesis).
Science at Chemistry-Biology Interface (Chemical informatics; Macromolecular catalysts and receptors; Enzymatic synthesis; Biosynthetic engineering; Combinatorial biosynthesis; Plant cell based chemistry; Bacterial and viral cell based chemistry; Chemistry of cellular processes in plants/animals; Receptor chemistry; Cell signaling chemistry; Drug design through understanding of disease processes; Synthetic biology; New high throughput screening techniques; Small molecular array fabrication; Chemical genomics; Chemical and biological approaches to carbohydrates proteins and nucleic acids design; Chemical and biological regulation of biosynthetic pathways; and Unnatural biomolecular analogs).
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