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Home / Current Chemical Biology, Volume 5, Number 1

Chlamydia-Secreted Proteins in Chlamydial Interactions with Host Cells

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Chlamydial interactions with host cells rely on chlamydia-secreted proteins, including preexisting and newly synthesized proteins. The preexisting proteins released from EBs participate in both chlamydial entry and intracellular survival at the early stage while the newly synthesized proteins secreted from RBs can both manipulate host cell signaling pathways and promote chlamydial reinfection. Despite the significant progresses made in the past decade, the precise mechanisms on what and how chlamydia-secreted proteins interact with host cells remain largely unknown, and will therefore still represent major research directions of the chlamydial field in the foreseeable future. Development of more effective methodologies will aid in discovery of new secretion molecules and novel mechanisms utilized in chlamydial interactions with host cells. The continuing accumulation of knowledge on chlamydia-secreted proteins and their mechanism of action may lead to discovery of novel prevention and therapeutic reagents for preventing and controlling chlamydial infection and pathologies.





Keywords: Bioinformatics; Cell-Fractionation; Chlamydia; Gel Resolution; Golgi apparatus; HIV invasion; Heterologous Secretion Systems; Major Outer Membrane Protein; Protochlamydia amoebophila; T cells; Yersinia; amoeba's; antibodies; cell nuclei; centrosome; chloramphenicol; cholesterol; cytokinesis; cytoplasm; cytoplasmic vacuole; cytoskeleton; cytosol; cytosolic fraction; cytotoxin homologues; effectors; elementary body; endocytic pathway; epithelial cell; estrogen receptors; fluorescence microscope; glycosaminoglycan; gram-negative bacteria; growth factor; heparin sulfate-like; heterologous systems; host cell; host-pathogen interactions; hybrid; infection; inflammatory; insulin; intracellular growth cycle; kinases; lipids; lumen; lymphocytes; mammalian cells; microinjection; mitochondrial cytochrome; multiple ligand; neutralization; nonphagocytic; nutrients; parasite acquisition; parasitic replication; pathogenesis; pathogenesis-relevant; perfringolysin; phosphorylation; platelet; pneumoniae; protein disulfate isomerase; proteome array; retinoblastoma protein; scaffold protein; secretion; sphingomyelin; trachomatis; translocated actin-recruiting phosphoprotein (TARP)

Document Type: Research Article

Publication date: 01 January 2011

More about this publication?
  • Current Chemical Biology aims to publish full-length and mini reviews on exciting new developments at the chemistry-biology interface, covering topics relating to Chemical Synthesis, Science at Chemistry-Biology Interface and Chemical Mechanisms of Biological Systems.

    Current Chemical Biology covers the following areas: Chemical Synthesis (Syntheses of biologically important macromolecules including proteins, polypeptides, oligonucleotides, oligosaccharides etc.; Asymmetric synthesis; Combinatorial synthesis; Diversity-oriented synthesis; Template-directed synthesis; Biomimetic synthesis; Solid phase biomolecular synthesis; Synthesis of small biomolecules: amino acids, peptides, lipids, carbohydrates and nucleosides; and Natural product synthesis).

    Science at Chemistry-Biology Interface (Chemical informatics; Macromolecular catalysts and receptors; Enzymatic synthesis; Biosynthetic engineering; Combinatorial biosynthesis; Plant cell based chemistry; Bacterial and viral cell based chemistry; Chemistry of cellular processes in plants/animals; Receptor chemistry; Cell signaling chemistry; Drug design through understanding of disease processes; Synthetic biology; New high throughput screening techniques; Small molecular array fabrication; Chemical genomics; Chemical and biological approaches to carbohydrates proteins and nucleic acids design; Chemical and biological regulation of biosynthetic pathways; and Unnatural biomolecular analogs).
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