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A Review on Synthesis, Anticancer and Antiviral Potentials of Pyrimidine Derivatives

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Background: Pyrimidine is the six membered heterocyclic aromatic compound similar to benzene and pyridine containing two nitrogen atoms at 1st and 3rd positions. Pyrimidine is present throughout nature in various forms and is the building blocks of numerous natural compounds from antibiotics to vitamins and liposacharides. The most commonly recognized pyrimidines are the bases of RNA and DNA, the most abundant being cytosine, thymine or uracil.

Results: Pyrimidine is a core structure in a wide variety of compounds that exhibits significant biological activity and also plays an important role in the drug discovery process. Various synthetic aspects indicated that pyrimidine derivatives are easy to synthesize and has diverse biological and chemical applications. The present review article aims to review the work reported on synthesis, anticancer and antiviral potentials of pyrimidine derivatives during new millennium.

Conclusion: It may be concluded that the fused pyrimidine derivatives enhanced the anticancer potential against different human cancer cell lines and antiviral potential against different human immunodeficiency virus (HIV), herpes simplex virus (HSV-1) etc, which created interest among the medicinal chemists in the pyrimidine skeleton in medicinal chemistry. Thus, a tremendous scope for research is present in this direction for investigating pyrimidine derivatives as lead molecules.
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Keywords: Pyrimidine derivatives; anticancer activity; antiviral activity; human leukaemia; malignancy; synthesis

Document Type: Review Article

Publication date: June 1, 2019

More about this publication?
  • The journal aims to provide updates to researchers about new bioactive compounds with proven activities in various biological screenings and pharmacological models. The journal will contain information about the structures, biological activities and sources of chemical entities discovered or designed by researchers and published in leading journals. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.

    The journal should prove to be essential reading for pharmacologists, pharmaceutical chemists and medicinal chemists who wish to be kept informed and up-to-date with the latest and most important developments about new bioactive compounds of natural or synthetic origin, including recent patents.
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