Skip to main content
padlock icon - secure page this page is secure

Preparation and Antioxidant Capacity Test of Praziquantel Nanoemulsion

Buy Article:

$68.00 + tax (Refund Policy)

Background: Praziquantel (Prz)-induced membrane permeability causes cell death of organisms. It may have antioxidative/pro-oxidative capacity. The aim of this study was to prepare Prz nanoemulsion and evaluate antioxidant capacity.

Materials and Methods: Radical scavenging capacity was checked by 1,1-dipheny-picrylhydrazyl (DPPH), azino-bisethylbenzthiazoline-sulfonic acid (ABTS); hydroxyl (OH) and nitrite oxide (NO) radical assays, while lipid peroxidation was done by thiobarbitiric acid substances (TBARS), reduction potential (RP) by ferric reduction, and membrane protection by hemolysis (HL) inhibition test in rat erythrocytes taking Trolox (TRO), an α-tocopherol analogue as a positive control. Additionally, an oxidative/antioxidative potential of PrzNE was checked in a wild type (SOD-WT) and deficient (SOD1Δ, SOD2Δ, CAT1Δ, SOD1ΔSOD2Δ and SOD1ΔCAT1Δ) Saccharomyces cerevisiae strains using hydrogen peroxide (H2O2) as a stressor.

Results: PrzNE, in a concentration-dependent manner, scavenged free radicals. It significantly (p <0.05) scavenged NO and OH radicals. PrzNE, alone induced slight oxidative stress, while in cotreatment, it significantly (p <0.05) protected S. cerevisiae strains from the damaging effect of H2O2.

Conclusion: The OH and NO radical scavenging capacity may be linked to the protective effect of the RBCs membrane and S. cerevisiae cells. PrzNE exerted a moderate antioxidative capacity.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Antioxidant; Rattus norvegicus; Saccharomyces cerevisiae; nanoemulsion; praziquantel

Document Type: Research Article

Publication date: March 1, 2018

More about this publication?
  • The journal aims to provide updates to researchers about new bioactive compounds with proven activities in various biological screenings and pharmacological models. The journal will contain information about the structures, biological activities and sources of chemical entities discovered or designed by researchers and published in leading journals. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.

    The journal should prove to be essential reading for pharmacologists, pharmaceutical chemists and medicinal chemists who wish to be kept informed and up-to-date with the latest and most important developments about new bioactive compounds of natural or synthetic origin, including recent patents.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more