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Non-Clinical Screening of Cyto-Genotoxicologic Status of Praziquantel Nanoemulsion

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Background: Prazequantel (Prz) is an important medication in humans and animals. It acts against a number of pathogens. In this study, Prz nanoemulsion (PrzNE) was prepared and evaluated for toxic, cytotoxic and mutagenic potentials.

Materials and Methods: The cytotoxic effect of PrzNE was observed in Artemia salina and Allium cepa, while toxicity and mutegenicity in A. cepa test system. Potassium di-chromate (K2Cr2O7) and copper sulphate (CuSO4.5H2O) were taken as standards for A. salina and A. cepa test, respectively.

Results: PrzNE at 16 μM caused 100% mortality of the brine shripms. It exerted a concentrationdependent toxic and cytotoxic effects in A. cepa and A. salina. In comparison to the CuSO4.5H2O, PrzNE produced less chromosomal aberrations (CA), where chromosomal fragments/loose and bridges were most frequently observed.

Conclusion: PrzNE may readily cross the cell membranes of A. cepa and A. salina, increase the permeability of the cell membrane and/or exert an oxidative stress, thus causes a cytotoxic effect. The PrzNE was more cytotoxic than mutagenic in nature.
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Keywords: Cytotoxicity; budding parenchyma; enzymes; hypotension; mutagenicity; praziquantel nanoemulsion

Document Type: Research Article

Publication date: March 1, 2018

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    The journal should prove to be essential reading for pharmacologists, pharmaceutical chemists and medicinal chemists who wish to be kept informed and up-to-date with the latest and most important developments about new bioactive compounds of natural or synthetic origin, including recent patents.
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