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Synthesis of Some Novel Substituted Phenyl β, β-Diphenyl Propanoate with Analgesic and Anti-inflammatory Activity

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Background: In the present study, a series of substituted phenyl β,β-diphenylpropanoate were synthesized by the reaction of β,β-diphenylpropionyl chloride with various substituted phenols in acetone.

Methods: Upon synthesis of compounds, the characterization of synthesized compounds was made using IR, NMR, Mass spectroscopy and elemental anaysis. These derivatives were screened for analgesic activity and anti-inflammatory activity (Carrageen induced paw edema method) Diclofenac sodium and Indomethacin were used as standard drug for analgesic activity and anti-inflammatory response, respectively.

Results: The compounds 2-nitro Phenyl 3,3 diphenyl propionate (HD-5) and 4-nitro Phenyl 3,3 diphenyl propionate (HD-2) exhibited significantlly potent anti-inflammatory and analgesic activity (two to three times) when comparision was made with control group. The response of promising compound (HD-5) for analgesic and anti-inflammatory action was highest among all the test compound and was almost similar to the standard compounds (Indomethacin and Diclofenac Sodium).

Conclusion: The findings of present work confirm the potent action of HD-5 compounds as analgesic and anti-pyretic in experimental animals.
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Keywords: Aryl propionic acid; analgesic activity; anti-inflammatory activity; biosynthesis; potency; ulceration

Document Type: Research Article

Publication date: March 1, 2018

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  • The journal aims to provide updates to researchers about new bioactive compounds with proven activities in various biological screenings and pharmacological models. The journal will contain information about the structures, biological activities and sources of chemical entities discovered or designed by researchers and published in leading journals. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.

    The journal should prove to be essential reading for pharmacologists, pharmaceutical chemists and medicinal chemists who wish to be kept informed and up-to-date with the latest and most important developments about new bioactive compounds of natural or synthetic origin, including recent patents.
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