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Natural Occurring β-Peptides: A Fascinating World of Bioactive Molecules

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Background: Living organisms are a natural source of β-amino acids and peptides containing them. Many marine organisms and plants are able to produce by themselves such compounds, e.g. depsi-peptides and macrocyclic molecules, which possess different biological activities, mostly concerned to the treatment of human diseases.

Methods: Literature has been collected ranging from 1980 until now; both reviews and research articles have been carefully considered and cited in our paper.

Results: Literature revealed an increased interest in natural bioactive peptides incorporating β-amino acids. Several papers focused their attention on structural characteristics of depsipeptides and cyclic compounds incorporating them in marine organisms, which may influence and determine the specific biological activity in vivo.

Conclusion: In this brief review, we collect a series of naturally occurring peptides incorporating β- amino acids, with the aim to update the arsenal of bioactive compounds available, highlighting the significant structural modifications which are the base of the exerting biological properties.
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Keywords: biological effects; human health; secondary structure; β-aminoacids; β-peptides

Document Type: Review Article

Publication date: March 1, 2018

More about this publication?
  • The journal aims to provide updates to researchers about new bioactive compounds with proven activities in various biological screenings and pharmacological models. The journal will contain information about the structures, biological activities and sources of chemical entities discovered or designed by researchers and published in leading journals. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.

    The journal should prove to be essential reading for pharmacologists, pharmaceutical chemists and medicinal chemists who wish to be kept informed and up-to-date with the latest and most important developments about new bioactive compounds of natural or synthetic origin, including recent patents.
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