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Synthetic Ion Channels As Novel Antimicrobial Agents

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Several families of novel synthetic ion channels have now been developed. They exhibit many, but not all, of the properties of protein ion channels. Some are peptides, but none is naturally occurring. Their ability to insert in membranes and disrupt ion homeostasis confers cellular toxicity upon them. Because these compounds are both abiotic and cytotoxic to a range of microbes, they have been investigated as antibiotics.





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Keywords: ANTIBIOTICS; alpha-helical conformation; hydraphiles; minimum bactericidal concentration (MBC); synthetic ion transporters

Document Type: Research Article

Affiliations: Department of Molecular Biology & Pharmacology, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8103, St. Louis, MO 63110, USA.

Publication date: March 1, 2006

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  • The journal aims to provide updates to researchers about new bioactive compounds with proven activities in various biological screenings and pharmacological models. The journal will contain information about the structures, biological activities and sources of chemical entities discovered or designed by researchers and published in leading journals. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.

    The journal should prove to be essential reading for pharmacologists, pharmaceutical chemists and medicinal chemists who wish to be kept informed and up-to-date with the latest and most important developments about new bioactive compounds of natural or synthetic origin, including recent patents.
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