Skip to main content
padlock icon - secure page this page is secure

Synthetic Ion Channels As Novel Antimicrobial Agents

Buy Article:

$68.00 + tax (Refund Policy)

Several families of novel synthetic ion channels have now been developed. They exhibit many, but not all, of the properties of protein ion channels. Some are peptides, but none is naturally occurring. Their ability to insert in membranes and disrupt ion homeostasis confers cellular toxicity upon them. Because these compounds are both abiotic and cytotoxic to a range of microbes, they have been investigated as antibiotics.

No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: ANTIBIOTICS; alpha-helical conformation; hydraphiles; minimum bactericidal concentration (MBC); synthetic ion transporters

Document Type: Research Article

Affiliations: Department of Molecular Biology & Pharmacology, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8103, St. Louis, MO 63110, USA.

Publication date: March 1, 2006

More about this publication?
  • The journal aims to provide updates to researchers about new bioactive compounds with proven activities in various biological screenings and pharmacological models. The journal will contain information about the structures, biological activities and sources of chemical entities discovered or designed by researchers and published in leading journals. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.

    The journal should prove to be essential reading for pharmacologists, pharmaceutical chemists and medicinal chemists who wish to be kept informed and up-to-date with the latest and most important developments about new bioactive compounds of natural or synthetic origin, including recent patents.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more