Skip to main content
padlock icon - secure page this page is secure

Inhibitors of Protein-Protein Interactions as Potential Drugs

Buy Article:

$68.00 + tax (Refund Policy)

Protein-protein interactions play a crucial role in numerous vital cell functions. However proteinprotein interactions are also responsible for pathological formation of protein aggregates, which determine the development of several diseases. The key role of protein-protein interactions for manifestation of numerous cell functions attracts much attention to protein complexes as perspective drug targets. So design or discovery of small molecules that would regulate protein-protein interactions represents great pharmacological interest. The recent progress in understanding of mechanism protein-protein interaction, including role of flexibility of protein-protein interfaces, thermodynamic of complex formation, discovery of small molecules modifying protein-protein interactions, the advantages and limitation of protein-protein inhibitors as potential drugs are discussed in this review.





No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Protein-protein interaction; allosteric inhibition; dimerization; drug; flexibility; inhibitors; target

Document Type: Research Article

Affiliations: Institute of Biomedical Chemistry, Pogodinskaya Str., 10, Moscow, 119121, Russia.

Publication date: March 1, 2007

More about this publication?
  • Current Computer-Aided Drug Design aims to publish all the latest developments in drug design based on computational techniques. The field of computer-aided drug design has had extensive impact in the area of drug design. Current Computer-Aided Drug Design is an essential journal for all medicinal chemists who wish to be kept informed and up-to-date with all the latest and important developments in computer-aided methodologies and their applications in drug discovery. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of computational techniques for drug design, screening, ADME studies, etc., providing excellent rationales for drug development.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more