Skip to main content
padlock icon - secure page this page is secure

A Pilot Study of Hippocampal Activity During a Verbal Memory Task in Depressed Young Adults

Buy Article:

$68.00 + tax (Refund Policy)

Background: Hippocampal volume is reduced in Major Depressive Disorder (MDD), but the extent to which hippocampal function is altered in the context of MDD, particularly in young adults, is not well established. The hippocampus is important in recollection memory, a cognitive domain that is often impaired in depressed adults.

Objective: This pilot functional Magnetic Resonance Imaging (fMRI) study aimed to assess hippocampal activity during a verbal memory task in unmedicated young adults with MDD (18-24 years of age) relative to healthy age-matched Controls.

Method: Brain activity was measured in hippocampal regions during verbal encoding and retrieval, and compared between groups (N=11 in each group); exploratory whole-brain assessments were also carried out.

Results: Greater right hippocampal activity during verbal memory encoding (vs. retrieval) was apparent in Controls. Further, in the MDD group, left hippocampal activity during encoding (vs. retrieval) was positively related to depression symptom severity and number of previous depressive episodes.

Conclusion: This pilot study is a stepping stone in examining the effect of depression on hippocampal function in young adults.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Depression; MDD; fMRI; hippocampus; memory; youth

Document Type: Research Article

Publication date: April 1, 2018

More about this publication?
  • Adolescent Psychiatry publishes reports of original research, critical reviews of topics relevant to practitioners, clinical observations with analysis and discussion, analysis of philosophical, ethical or social aspects of the fields of psychiatry and mental health, case reports with discussions, letters, and position papers. Adolescent Psychiatry, a peer-reviewed journal, and the official journal of the American Society for Adolescent Psychiatry, aims to provide mental health professionals who work with adolescents with current information relevant to the diagnosis and treatment of psychiatric disorders in adolescence.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more