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Prenyloxyphenylpropanoids as a Novel Class of Anti-inflammatory Agents

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Oxyprenylated natural products (isopentenyloxy-, geranyloxy- and the less spread farnesyloxy- compounds and their biosynthetic derivatives) represent a family of secondary metabolites that have been considered for years just as biosynthetic intermediates of the most naturally widespread C-prenylated derivatives. Only in the last decade have these natural products been recognized as interesting and valuable biologically active phytochemicals. Up to now about 300 molecules were isolated from plants mainly belonging to the families of Rutaceae, Apiaceae, and Compositae, comprising common edible vegetables and fruits. A wide variety of compounds containing a prenyloxy side chain has been isolated and among these coumarins, cinnamic acids and aromatic ketones displayed the most efficient and promising biological activities as anti-inflammatory agents. The aim of this review is to examine in detail the anti-inflammatory properties of these novel class of natural products.





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Keywords: Anti-inflammatory activity; prenyloxycinnamic acids; prenyloxycoumarins; rutaceae

Document Type: Research Article

Publication date: June 1, 2010

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  • Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Anti-Inflammatory & Anti-Allergy Agents.

    Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Anti-Inflammatory & Anti-Allergy Medicinal Chemistry.

    Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in Anti-Inflammatory & Anti-Allergy Agents drug discovery.
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