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Chemoprevention of Colorectal Carcinogenesis by Natural Anti-Inflammatory Agents

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Accumulating epidemiological, clinical, and experimental evidence demonstrates that chronic inflammation plays a critical role in multistep oncogenesis. While long-term users of selective cycloxygenase (COX)-2 inhibitors (- coxibs) and non-steroidal anti-inflammatory drugs (NSAIDs) exert a reduced risk of development of certain types of cancer, including colorectal cancer (CRC), the adverse gastrointestinal and cardiovascular side effects associated with these drugs have limited their daily use for cancer chemoprevention. The role of various proinflammatory mediators during carcinogenesis and their promise as potential targets for chemoprevention of inflammation-associated carcinogenesis has been recently highlighted. A variety of chemopreventive phytochemicals and phytonutrients are able to alter or correct undesired cellular functions caused by abnormal pro-inflammatory signal transmissions that are mediated by NF-kappaB, etc. Modulation of cellular signaling involved in chronic inflammatory responses, induced by anti-inflammatory agents, hence provides a rational and practical strategy in molecular target-based cancer chemoprevention. This short review will focus on the role of chronic inflammation in colorectal oncogenesis and introduce dietary cancer chemopreventive agents with anti-inflammatory activity.





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Keywords: Colon carcinogenesis; carotenoid; chemoprevension; flavonoid; inflammation

Document Type: Research Article

Publication date: June 1, 2010

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  • Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Anti-Inflammatory & Anti-Allergy Agents.

    Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Anti-Inflammatory & Anti-Allergy Medicinal Chemistry.

    Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in Anti-Inflammatory & Anti-Allergy Agents drug discovery.
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