Skip to main content
padlock icon - secure page this page is secure

Synthesis, Biological Evaluation, in Silico Docking and Virtual ADME Studies of Novel Isatin Analogs as Promising Antimicrobial Agents

Buy Article:

$68.00 + tax (Refund Policy)

Background: A series of sixteen novel isatin analogs (3a-3p) have been synthesized and evaluated for their antibacterial and antifungal activities against various pathogenic microorganisms. Gram-positive bacterial strains: Staphylococcus aureus, Bacillus subtilis; Gram-negative bacterial strains: Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella pneumonia, and fungal strains Candida albicans, Aspergillus niger use two fold serial dilution method. Methods: Some of the synthesized compounds showed promising antibacterial and antifungal activities among the series. Results: Compound 3l shows the best antimicrobial activity which is substantiated by the highest docking score. Conclusion: Structure activity relationships (SAR) as well as virtual ADMET studies were carried out and a connection between activities, electronic and physicochemical properties of the target compounds was determined.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Antimicrobial activity; Isatin; SAR study; in silico study; lipinski’s rule

Document Type: Research Article

Publication date: August 1, 2015

More about this publication?
  • Anti-Infective Agents publishes original research, expert reviews, drug clinical trial studies and guest edited issues on all the latest and outstanding developments on the medicinal chemistry, biology, pharmacology and use of anti-infective and anti-parasitic agents. The scope of the journal covers all pre-clinical and clinical research on antimicrobials, antibacterials, antiviral, antifungal, and antiparasitic agents. Anti-Infective Agents is an essential journal for all infectious disease researchers in industry, academia and the health services.
  • Editorial Board
  • Information for Authors
  • Submit a Paper
  • Subscribe to this Title
  • Information for Advertisers
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more