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Antibacterial Properties of Tetraalkylammonium and Imidazolium Tetraalkoxycalix[4]arene Derivatives

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The antibacterial and antibiofilm activities of several amphiphillic tetracationic calixarenes with different functional groups were evaluated. Our results demonstrate the clear dependence of antibacterial activity from the alkyl chain length on the lower rim of calixarene. Tetrapropoxycalixarenes have 10-50 times higher antibacterial activity than tetraoctyl calixarenes with same cationic residues on the upper rim. At the same time, one of the tetrapropoxycalixarenes shows high inhibitory activity against Staphylococcus aureus biofilms. Therefore, the alkyl chain length is an important characteristic that can be used for further antibacterial agent design.
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Keywords: Antibacterial; QAS; biofilm; calixarene; structure-activity relationship

Document Type: Research Article

Publication date: April 1, 2015

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  • Anti-Infective Agents publishes original research, expert reviews, drug clinical trial studies and guest edited issues on all the latest and outstanding developments on the medicinal chemistry, biology, pharmacology and use of anti-infective and anti-parasitic agents. The scope of the journal covers all pre-clinical and clinical research on antimicrobials, antibacterials, antiviral, antifungal, and antiparasitic agents. Anti-Infective Agents is an essential journal for all infectious disease researchers in industry, academia and the health services.
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